4GKH
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NA-PP1
Summary for 4GKH
Entry DOI | 10.2210/pdb4gkh/pdb |
Related | 4EJ7 4FEU 4FEV 4FEW 4FEX 4GKI |
Descriptor | Aminoglycoside 3'-phosphotransferase AphA1-IAB, KANAMYCIN A, 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ... (8 entities in total) |
Functional Keywords | pyrazolopyrimidine, 1-na-pp1, bumped kinase inhibitor, bki, protein kinase inhibitor, center for structural genomics of infectious diseases, csgid, niaid, national institute of allergy and infectious diseases, transferase-transferase inhibitor complex, eukaryotic protein kinase-like fold, alpha/beta protein, transferase, phosphotransferase, aminoglycoside phosphotransferase, antibiotic resistance, aminoglycosides, kanamycin, gtp, intracellular, transferase/transferase inhibitor |
Biological source | Acinetobacter baumannii |
Total number of polymer chains | 12 |
Total formula weight | 388664.20 |
Authors | Stogios, P.J.,Evdokimova, E.,Wawrzak, Z.,Minasov, G.,Egorova, O.,Di Leo, R.,Shakya, T.,Spanogiannopoulos, P.,Todorovic, N.,Capretta, A.,Wright, G.D.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-08-11, release date: 2012-09-05, Last modification date: 2023-12-06) |
Primary citation | Stogios, P.J.,Spanogiannopoulos, P.,Evdokimova, E.,Egorova, O.,Shakya, T.,Todorovic, N.,Capretta, A.,Wright, G.D.,Savchenko, A. Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. Biochem.J., 454:191-200, 2013 Cited by PubMed: 23758273DOI: 10.1042/BJ20130317 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.863 Å) |
Structure validation
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