4GKH
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NA-PP1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0005524 | molecular_function | ATP binding |
| B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| B | 0046677 | biological_process | response to antibiotic |
| C | 0005524 | molecular_function | ATP binding |
| C | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| C | 0046677 | biological_process | response to antibiotic |
| D | 0005524 | molecular_function | ATP binding |
| D | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| D | 0046677 | biological_process | response to antibiotic |
| E | 0005524 | molecular_function | ATP binding |
| E | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| E | 0046677 | biological_process | response to antibiotic |
| F | 0005524 | molecular_function | ATP binding |
| F | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| F | 0046677 | biological_process | response to antibiotic |
| G | 0005524 | molecular_function | ATP binding |
| G | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| G | 0046677 | biological_process | response to antibiotic |
| H | 0005524 | molecular_function | ATP binding |
| H | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| H | 0046677 | biological_process | response to antibiotic |
| I | 0005524 | molecular_function | ATP binding |
| I | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| I | 0046677 | biological_process | response to antibiotic |
| J | 0005524 | molecular_function | ATP binding |
| J | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| J | 0046677 | biological_process | response to antibiotic |
| K | 0005524 | molecular_function | ATP binding |
| K | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| K | 0046677 | biological_process | response to antibiotic |
| L | 0005524 | molecular_function | ATP binding |
| L | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| L | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE KAN A 301 |
| Chain | Residue |
| A | GLN35 |
| A | GLU269 |
| A | PHE271 |
| A | HOH405 |
| A | HOH427 |
| A | HOH450 |
| A | HOH480 |
| A | HOH482 |
| A | HOH491 |
| A | HOH661 |
| B | SER2 |
| A | ASP165 |
| B | HIS3 |
| K | ARG6 |
| A | PHE166 |
| A | ASP167 |
| A | ASP198 |
| A | ARG219 |
| A | ASN234 |
| A | CYS235 |
| A | ASP268 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 0J9 A 302 |
| Chain | Residue |
| A | ASP31 |
| A | ILE40 |
| A | PHE53 |
| A | PRO82 |
| A | THR99 |
| A | ALA100 |
| A | ILE101 |
| A | ILE215 |
| A | ACT305 |
| A | HOH409 |
| B | GLN5 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 303 |
| Chain | Residue |
| A | GLY159 |
| A | HOH456 |
| C | HOH536 |
| K | HOH426 |
| K | HOH474 |
| K | HOH605 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 304 |
| Chain | Residue |
| A | VAL109 |
| A | SER116 |
| A | GLY209 |
| A | HOH511 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 305 |
| Chain | Residue |
| A | VAL33 |
| A | THR105 |
| A | ASP202 |
| A | 0J9302 |
| B | HOH453 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 306 |
| Chain | Residue |
| A | GLY37 |
| A | THR39 |
| A | HIS56 |
| A | GLY57 |
| A | LYS58 |
| A | VAL61 |
| A | HOH597 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE KAN B 301 |
| Chain | Residue |
| B | ASP165 |
| B | ASP167 |
| B | ASP198 |
| B | ASN234 |
| B | CYS235 |
| B | GLU238 |
| B | ASP268 |
| B | GLU269 |
| B | PHE271 |
| B | HOH404 |
| B | HOH432 |
| B | HOH433 |
| B | HOH434 |
| B | HOH539 |
| B | HOH540 |
| B | HOH552 |
| B | HOH559 |
| B | HOH573 |
| B | HOH597 |
| B | HOH640 |
| H | GLY252 |
| H | ASP254 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 0J9 B 302 |
| Chain | Residue |
| B | ILE40 |
| B | PHE53 |
| B | PRO82 |
| B | ILE101 |
| B | ASP216 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 303 |
| Chain | Residue |
| B | THR76 |
| B | MSE79 |
| B | HOH528 |
| B | HOH631 |
| B | HOH647 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 304 |
| Chain | Residue |
| B | ASN234 |
| B | HOH432 |
| B | HOH458 |
| B | HOH474 |
| B | HOH486 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 305 |
| Chain | Residue |
| B | TYR113 |
| B | SER116 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 306 |
| Chain | Residue |
| B | HOH605 |
| B | GLY37 |
| B | ALA38 |
| B | THR39 |
| B | HIS56 |
| B | LYS58 |
| B | VAL61 |
| site_id | BC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE KAN C 301 |
| Chain | Residue |
| C | GLN35 |
| C | ASP165 |
| C | ASP167 |
| C | ASP198 |
| C | ARG219 |
| C | ASN234 |
| C | CYS235 |
| C | GLU238 |
| C | ASP268 |
| C | GLU269 |
| C | PHE271 |
| C | HOH423 |
| C | HOH430 |
| C | HOH448 |
| C | HOH455 |
| C | HOH459 |
| C | HOH463 |
| C | HOH508 |
| C | HOH518 |
| C | HOH546 |
| C | HOH588 |
| C | HOH620 |
| C | HOH636 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 0J9 C 302 |
| Chain | Residue |
| C | ASP31 |
| C | ASN32 |
| C | PHE53 |
| C | PRO82 |
| C | ALA100 |
| C | ILE101 |
| C | ILE215 |
| C | HOH425 |
| C | HOH462 |
| D | GLN5 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 0J9 C 303 |
| Chain | Residue |
| C | GLN5 |
| D | PHE53 |
| D | PRO82 |
| D | THR99 |
| D | ILE101 |
| D | ASP216 |
| D | HOH475 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 304 |
| Chain | Residue |
| C | THR76 |
| C | MSE79 |
| C | ACT307 |
| C | HOH449 |
| C | HOH533 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 305 |
| Chain | Residue |
| C | GLN35 |
| C | SER36 |
| C | ALA38 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT C 306 |
| Chain | Residue |
| C | VAL109 |
| C | SER116 |
| C | GLY209 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 307 |
| Chain | Residue |
| C | THR76 |
| C | ALA77 |
| C | MSE79 |
| C | PRO80 |
| C | NA304 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT C 308 |
| Chain | Residue |
| C | ARG30 |
| H | LEU243 |
| H | HOH498 |
| site_id | CC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE KAN D 301 |
| Chain | Residue |
| D | ASP165 |
| D | ASP167 |
| D | ASP198 |
| D | ASN234 |
| D | CYS235 |
| D | GLU238 |
| D | ASP268 |
| D | GLU269 |
| D | PHE271 |
| D | HOH414 |
| D | HOH415 |
| D | HOH418 |
| D | HOH420 |
| D | HOH429 |
| D | HOH433 |
| D | HOH512 |
| D | HOH527 |
| D | HOH538 |
| D | HOH556 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT D 302 |
| Chain | Residue |
| D | GLY37 |
| D | THR39 |
| D | HIS56 |
| D | GLY57 |
| D | LYS58 |
| D | VAL61 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 303 |
| Chain | Residue |
| D | PRO187 |
| D | PHE188 |
| D | SER189 |
| D | HOH453 |
| I | ARG14 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT D 304 |
| Chain | Residue |
| D | PHE107 |
| D | GLU111 |
| D | GLU238 |
| L | GLU176 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 305 |
| Chain | Residue |
| D | THR76 |
| D | ALA77 |
| D | MSE79 |
| D | PRO80 |
| D | ARG130 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG D 306 |
| Chain | Residue |
| D | ARG129 |
| D | SER133 |
| D | ARG225 |
| D | TYR251 |
| D | HOH567 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG D 307 |
| Chain | Residue |
| D | TYR113 |
| D | ASN119 |
| D | GLY209 |
| site_id | DC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE KAN E 301 |
| Chain | Residue |
| E | GLN35 |
| E | ASP165 |
| E | PHE166 |
| E | ASP167 |
| E | ASP198 |
| E | ARG219 |
| E | ASN234 |
| E | ASP268 |
| E | GLU269 |
| E | PHE271 |
| E | HOH403 |
| E | HOH407 |
| E | HOH420 |
| E | HOH425 |
| E | HOH427 |
| E | HOH462 |
| E | HOH496 |
| E | HOH512 |
| F | SER2 |
| F | HIS3 |
| F | HOH488 |
| G | ARG6 |
| site_id | DC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 0J9 E 302 |
| Chain | Residue |
| E | ASP31 |
| E | ILE40 |
| E | PHE53 |
| E | PRO82 |
| E | ALA100 |
| E | ILE101 |
| E | ILE215 |
| E | ASP216 |
| E | ACT306 |
| E | HOH413 |
| E | HOH439 |
| F | GLN5 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA E 303 |
| Chain | Residue |
| E | GLY159 |
| E | HOH482 |
| G | HOH413 |
| G | HOH473 |
| I | HOH660 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT E 304 |
| Chain | Residue |
| E | GLY37 |
| E | THR39 |
| E | HIS56 |
| E | GLY57 |
| E | LYS58 |
| E | VAL61 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT E 305 |
| Chain | Residue |
| E | VAL109 |
| E | SER116 |
| E | GLY209 |
| E | HOH459 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT E 306 |
| Chain | Residue |
| E | VAL33 |
| E | ASP202 |
| E | 0J9302 |
| F | GLN5 |
| site_id | DC7 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE KAN F 301 |
| Chain | Residue |
| F | ASP165 |
| F | ASP167 |
| F | ASP198 |
| F | ARG219 |
| F | ASN234 |
| F | CYS235 |
| F | GLU238 |
| F | ASP268 |
| F | GLU269 |
| F | PHE271 |
| F | HOH409 |
| F | HOH415 |
| F | HOH429 |
| F | HOH432 |
| F | HOH446 |
| F | HOH468 |
| F | HOH477 |
| F | HOH492 |
| F | HOH507 |
| F | HOH528 |
| L | GLY252 |
| site_id | DC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 0J9 F 302 |
| Chain | Residue |
| F | ASN32 |
| F | PHE53 |
| F | PRO82 |
| F | ILE101 |
| F | ILE215 |
| F | HOH506 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA F 303 |
| Chain | Residue |
| F | THR76 |
| F | MSE79 |
| F | HOH486 |
| F | HOH623 |
| F | HOH643 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA F 304 |
| Chain | Residue |
| F | ASN234 |
| F | HOH409 |
| F | HOH419 |
| F | HOH453 |
| F | HOH462 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT F 305 |
| Chain | Residue |
| F | VAL109 |
| F | TYR113 |
| F | GLY209 |
| site_id | EC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT F 306 |
| Chain | Residue |
| F | MSE258 |
| F | GLN262 |
| F | HOH500 |
| site_id | EC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT F 307 |
| Chain | Residue |
| F | ARG129 |
| F | ARG225 |
| F | TYR251 |
| F | HOH565 |
| F | HOH625 |
| site_id | EC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT F 308 |
| Chain | Residue |
| F | GLY37 |
| F | ALA38 |
| F | THR39 |
| F | HIS56 |
| F | GLY57 |
| F | LYS58 |
| F | VAL61 |
| F | HOH586 |
| site_id | EC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE KAN G 301 |
| Chain | Residue |
| G | ASP165 |
| G | ASP167 |
| G | ASP198 |
| G | ASN234 |
| G | CYS235 |
| G | GLU238 |
| G | ASP268 |
| G | GLU269 |
| G | PHE271 |
| G | HOH411 |
| G | HOH414 |
| G | HOH422 |
| G | HOH431 |
| G | HOH448 |
| G | HOH480 |
| G | HOH482 |
| G | HOH483 |
| G | HOH495 |
| G | HOH504 |
| G | HOH579 |
| I | GLY252 |
| site_id | EC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 0J9 G 302 |
| Chain | Residue |
| G | PHE53 |
| G | PRO82 |
| G | ILE101 |
| G | ILE215 |
| G | HOH585 |
| G | HOH649 |
| site_id | EC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA G 303 |
| Chain | Residue |
| G | THR76 |
| G | MSE79 |
| G | ACT306 |
| G | HOH539 |
| G | HOH575 |
| site_id | EC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA G 304 |
| Chain | Residue |
| G | ASN234 |
| G | HOH411 |
| G | HOH421 |
| G | HOH453 |
| G | HOH467 |
| site_id | FC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT G 305 |
| Chain | Residue |
| G | VAL109 |
| G | TYR113 |
| G | SER116 |
| G | ILE120 |
| site_id | FC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT G 306 |
| Chain | Residue |
| G | ALA77 |
| G | PHE78 |
| G | MSE79 |
| G | PRO80 |
| G | NA303 |
| site_id | FC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT G 307 |
| Chain | Residue |
| G | TRP233 |
| G | MSE258 |
| G | GLN262 |
| G | HOH486 |
| site_id | FC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE KAN H 301 |
| Chain | Residue |
| G | SER2 |
| G | HIS3 |
| G | HOH503 |
| H | ASP165 |
| H | ASP167 |
| H | ASP198 |
| H | ASN234 |
| H | CYS235 |
| H | GLU238 |
| H | ASP268 |
| H | GLU269 |
| H | PHE271 |
| H | HOH424 |
| H | HOH429 |
| H | HOH439 |
| H | HOH443 |
| H | HOH448 |
| H | HOH478 |
| H | HOH499 |
| H | HOH511 |
| H | HOH548 |
| site_id | FC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 0J9 H 302 |
| Chain | Residue |
| G | GLN5 |
| H | ASP31 |
| H | VAL33 |
| H | PHE53 |
| H | PRO82 |
| H | ALA100 |
| H | ILE101 |
| H | ILE215 |
| H | ASP216 |
| H | ACT304 |
| H | HOH407 |
| H | HOH467 |
| site_id | FC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA H 303 |
| Chain | Residue |
| H | THR76 |
| H | MSE79 |
| H | ACT305 |
| H | HOH529 |
| H | HOH530 |
| site_id | FC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT H 304 |
| Chain | Residue |
| G | HOH449 |
| H | ASP202 |
| H | 0J9302 |
| site_id | FC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT H 305 |
| Chain | Residue |
| H | THR76 |
| H | ALA77 |
| H | PHE78 |
| H | MSE79 |
| H | PRO80 |
| H | NA303 |
| site_id | FC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG H 306 |
| Chain | Residue |
| D | ARG14 |
| H | SER116 |
| site_id | GC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE KAN I 301 |
| Chain | Residue |
| F | ARG6 |
| F | HOH476 |
| I | GLN35 |
| I | ASP165 |
| I | ASP167 |
| I | ASP198 |
| I | ARG219 |
| I | ASN234 |
| I | CYS235 |
| I | GLU238 |
| I | ASP268 |
| I | GLU269 |
| I | PHE271 |
| I | HOH424 |
| I | HOH425 |
| I | HOH447 |
| I | HOH494 |
| I | HOH507 |
| I | HOH542 |
| I | HOH558 |
| I | HOH600 |
| J | SER2 |
| J | HOH496 |
| site_id | GC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 0J9 I 302 |
| Chain | Residue |
| I | ASP31 |
| I | ILE40 |
| I | PHE53 |
| I | PRO82 |
| I | ALA100 |
| I | ILE101 |
| I | ILE215 |
| I | ASP216 |
| I | HOH446 |
| J | GLN5 |
| site_id | GC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA I 303 |
| Chain | Residue |
| I | THR76 |
| I | MSE79 |
| I | ACT305 |
| I | HOH456 |
| I | HOH492 |
| site_id | GC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL I 304 |
| Chain | Residue |
| I | GLN35 |
| I | SER36 |
| I | ALA38 |
| I | LYS55 |
| I | HOH476 |
| site_id | GC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT I 305 |
| Chain | Residue |
| I | THR76 |
| I | ALA77 |
| I | PHE78 |
| I | MSE79 |
| I | PRO80 |
| I | NA303 |
| site_id | GC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT I 306 |
| Chain | Residue |
| I | SER116 |
| I | HOH644 |
| site_id | GC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT I 307 |
| Chain | Residue |
| I | ASP202 |
| I | HOH653 |
| J | GLN5 |
| site_id | GC8 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE KAN J 301 |
| Chain | Residue |
| A | HOH536 |
| J | ASP165 |
| J | ASP167 |
| J | ASP198 |
| J | ASN234 |
| J | CYS235 |
| J | ASP268 |
| J | GLU269 |
| J | PHE271 |
| J | HOH409 |
| J | HOH426 |
| J | HOH435 |
| J | HOH436 |
| J | HOH454 |
| J | HOH468 |
| J | HOH483 |
| J | HOH540 |
| site_id | GC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 0J9 J 302 |
| Chain | Residue |
| J | ASP31 |
| J | ILE40 |
| J | PHE53 |
| J | PRO82 |
| J | THR99 |
| J | ALA100 |
| J | ILE101 |
| J | HOH516 |
| site_id | HC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT J 303 |
| Chain | Residue |
| J | GLY37 |
| J | ALA38 |
| J | THR39 |
| J | HIS56 |
| J | GLY57 |
| J | LYS58 |
| J | VAL61 |
| site_id | HC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE KAN K 301 |
| Chain | Residue |
| C | GLY252 |
| C | ASP254 |
| C | HOH403 |
| K | ASP165 |
| K | ASP167 |
| K | ASP198 |
| K | ASN234 |
| K | CYS235 |
| K | GLU238 |
| K | ASP268 |
| K | GLU269 |
| K | PHE271 |
| K | HOH409 |
| K | HOH421 |
| K | HOH429 |
| K | HOH462 |
| K | HOH463 |
| K | HOH505 |
| K | HOH506 |
| K | HOH513 |
| K | HOH528 |
| K | HOH529 |
| K | HOH584 |
| site_id | HC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 0J9 K 302 |
| Chain | Residue |
| K | ASP31 |
| K | PHE53 |
| K | PRO82 |
| K | THR99 |
| K | ILE101 |
| K | HOH559 |
| K | HOH582 |
| K | HOH598 |
| site_id | HC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA K 303 |
| Chain | Residue |
| K | THR76 |
| K | MSE79 |
| K | HOH481 |
| K | HOH601 |
| K | HOH658 |
| site_id | HC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA K 304 |
| Chain | Residue |
| C | HOH403 |
| K | ASN234 |
| K | HOH424 |
| K | HOH459 |
| K | HOH485 |
| site_id | HC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT K 305 |
| Chain | Residue |
| K | TRP233 |
| K | MSE258 |
| K | GLN262 |
| K | HOH547 |
| site_id | HC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT K 306 |
| Chain | Residue |
| K | TYR113 |
| K | SER116 |
| K | GLY209 |
| K | HOH647 |
| site_id | HC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT K 307 |
| Chain | Residue |
| K | GLY37 |
| K | ALA38 |
| K | HIS56 |
| K | GLY57 |
| K | LYS58 |
| K | VAL61 |
| site_id | HC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE KAN L 301 |
| Chain | Residue |
| J | ARG6 |
| K | SER2 |
| K | HIS3 |
| L | ASP165 |
| L | ASP167 |
| L | ASP198 |
| L | ASN234 |
| L | CYS235 |
| L | GLU238 |
| L | ASP268 |
| L | GLU269 |
| L | PHE271 |
| L | HOH422 |
| L | HOH439 |
| L | HOH442 |
| L | HOH463 |
| L | HOH465 |
| L | HOH469 |
| L | HOH490 |
| L | HOH521 |
| L | HOH652 |
| site_id | IC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 0J9 L 302 |
| Chain | Residue |
| L | ASP31 |
| L | VAL33 |
| L | PHE53 |
| L | PRO82 |
| L | ALA100 |
| L | ILE101 |
| L | ILE215 |
| L | ASP216 |
| L | ACT308 |
| L | HOH408 |
| L | HOH487 |
| site_id | IC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA L 303 |
| Chain | Residue |
| L | THR76 |
| L | MSE79 |
| L | ACT305 |
| L | HOH527 |
| L | HOH530 |
| site_id | IC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT L 304 |
| Chain | Residue |
| L | ASP20 |
| L | TYR24 |
| site_id | IC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT L 305 |
| Chain | Residue |
| F | GLN35 |
| L | THR76 |
| L | ALA77 |
| L | PHE78 |
| L | MSE79 |
| L | PRO80 |
| L | NA303 |
| site_id | IC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT L 307 |
| Chain | Residue |
| L | MSE258 |
| L | LEU261 |
| L | GLN262 |
| L | HOH631 |
| site_id | IC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT L 308 |
| Chain | Residue |
| K | GLN5 |
| L | THR105 |
| L | ASP202 |
| L | 0J9302 |
| L | HOH473 |
Functional Information from PROSITE/UniProt
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. VTHgDFSLDNLIF |
| Chain | Residue | Details |
| A | VAL194-PHE206 |
