4FBE

Crystal structure of the C136A/C164A variant of mitochondrial isoform of glutaminyl cyclase from Drosophila melanogaster

Summary for 4FBE

Entry DOI	10.2210/pdb4fbe/pdb
Related	4F9U 4F9V 4FAI
Descriptor	CG5976, isoform B, 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	alpha/beta hydrolase, pglu formation, pe, alzheimer's disease, pyroglutamate, pglu-amyloid, transferase, hydrolase
Biological source	Drosophila melanogaster (Fruit fly)
Total number of polymer chains	2
Total formula weight	76539.43
Authors	Kolenko, P.,Koch, B.,Ruiz-Carilo, D.,Stubbs, M.T. (deposition date: 2012-05-23, release date: 2012-08-29, Last modification date: 2023-09-13)
Primary citation	Koch, B.,Kolenko, P.,Buchholz, M.,Ruiz Carrillo, D.,Parthier, C.,Wermann, M.,Rahfeld, J.U.,Reuter, G.,Schilling, S.,Stubbs, M.T.,Demuth, H.U. Crystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs. Biochemistry, 51:7383-7392, 2012 Cited by PubMed: 22897232 DOI: 10.1021/bi300687g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation