4FBE
Crystal structure of the C136A/C164A variant of mitochondrial isoform of glutaminyl cyclase from Drosophila melanogaster
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CG5976, isoform B | polymer | 330 | 37866.2 | 2 | UniProt (Q86PD7) Pfam (PF04389) | Drosophila melanogaster (Fruit fly) | glutaminyl-peptide cyclotransferase, RE61650p |
| 2 | C, G (A, B) | 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea | non-polymer | 320.4 | 2 | Chemie (PBD) | |||
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | E, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 424 | Chemie (HOH) |
Sequence modifications
A, B: 32 - 354 (UniProt: Q86PD7)
| PDB | External Database | Details |
|---|---|---|
| Met 25 | - | expression tag |
| Arg 26 | - | expression tag |
| Gly 27 | - | expression tag |
| Ser 28 | - | expression tag |
| Thr 29 | - | expression tag |
| Asp 30 | - | expression tag |
| Pro 31 | - | expression tag |
| Ala 136 | Cys 136 | engineered mutation |
| Ala 158 | Cys 158 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75732.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 807.1 | |
| All* | Total formula weight | 76539.4 |
