4FBE
Crystal structure of the C136A/C164A variant of mitochondrial isoform of glutaminyl cyclase from Drosophila melanogaster
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016603 | molecular_function | glutaminyl-peptide cyclotransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016603 | molecular_function | glutaminyl-peptide cyclotransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PBD A 401 |
| Chain | Residue |
| A | ASP153 |
| A | ZN403 |
| A | HOH513 |
| A | GLU190 |
| A | GLU191 |
| A | TRP196 |
| A | ASP228 |
| A | GLU292 |
| A | PHE313 |
| A | TRP317 |
| A | HIS318 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 402 |
| Chain | Residue |
| A | ASN81 |
| A | HOH618 |
| B | ASN81 |
| B | GLU147 |
| B | HOH588 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 403 |
| Chain | Residue |
| A | ASP153 |
| A | GLU191 |
| A | HIS318 |
| A | PBD401 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 401 |
| Chain | Residue |
| B | ASP153 |
| B | GLU191 |
| B | HIS318 |
| B | PBD402 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PBD B 402 |
| Chain | Residue |
| B | ASP153 |
| B | GLU190 |
| B | GLU191 |
| B | ASP228 |
| B | LEU229 |
| B | GLU292 |
| B | PHE313 |
| B | TRP317 |
| B | HIS318 |
| B | ZN401 |
| B | HOH514 |
| B | HOH618 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q16769","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22897232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FAI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FBE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
