4F9V

Structure of C113A/C136A mutant variant of glycosylated glutaminyl cyclase from Drosophila melanogaster

Summary for 4F9V

• Entry DOI: 10.2210/pdb4f9v/pdb
• Related: 4F9U 4FAI 4FBE
• Descriptor: CG32412, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: alpha/beta hydrolase, pglu formation, pe, alzheimer's disease, pyroglutamate, pglu-amyloid, glycosylation, transferase, hydrolase
• Biological source: Drosophila melanogaster (Fruit fly)
• Total number of polymer chains: 2
• Total formula weight: 73254.49

Authors

Kolenko, P.,Koch, B.,Ruiz-Carilo, D.,Stubbs, M.T. (deposition date: 2012-05-21, release date: 2012-08-29, Last modification date: 2023-09-13)

• Primary citation: Koch, B.,Kolenko, P.,Buchholz, M.,Ruiz Carrillo, D.,Parthier, C.,Wermann, M.,Rahfeld, J.U.,Reuter, G.,Schilling, S.,Stubbs, M.T.,Demuth, H.U.; Crystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs.; Biochemistry, 51:7383-7392, 2012; PubMed: 22897232; DOI: 10.1021/bi300687g

Experimental method

X-RAY DIFFRACTION (2.1 Å)