4F9V
Structure of C113A/C136A mutant variant of glycosylated glutaminyl cyclase from Drosophila melanogaster
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CG32412 | polymer | 312 | 35277.5 | 2 | UniProt (Q9VRQ9) Pfam (PF04389) | Drosophila melanogaster (Fruit fly) | glutaminyl-peptide cyclotransferase, GH11174p |
| 2 | C (C) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G07617FP) | |||
| 3 | D (D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | E, G (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | F, H (A, B) | 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea | non-polymer | 320.4 | 2 | Chemie (PBD) | |||
| 6 | I (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | J, K (A, B) | water | water | 18.0 | 685 | Chemie (HOH) |
Sequence modifications
A, B: 29 - 340 (UniProt: Q9VRQ9)
| PDB | External Database | Details |
|---|---|---|
| Ala 113 | Cys 113 | engineered mutation |
| Ala 136 | Cys 136 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70555.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1821.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 877.8 | |
| All* | Total formula weight | 73254.5 |
