4FAI

Crystal structure of mitochondrial isoform of glutaminyl cyclase from Drosophila melanogaster

Summary for 4FAI

Entry DOI	10.2210/pdb4fai/pdb
Related	4F9U 4F9V 4FBE
Descriptor	CG5976, isoform B, ZINC ION, 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea, ... (5 entities in total)
Functional Keywords	alpha/beta hydrolase, pglu formation, pe, alzheimer's disease, pyroglutamate, pglu-amyloid, transferase, hydrolase
Biological source	Drosophila melanogaster (Fruit fly)
Total number of polymer chains	2
Total formula weight	76703.15
Authors	Kolenko, P.,Koch, B.,Ruiz-Carilo, D.,Stubbs, M.T. (deposition date: 2012-05-22, release date: 2012-08-29, Last modification date: 2023-09-13)
Primary citation	Koch, B.,Kolenko, P.,Buchholz, M.,Ruiz Carrillo, D.,Parthier, C.,Wermann, M.,Rahfeld, J.U.,Reuter, G.,Schilling, S.,Stubbs, M.T.,Demuth, H.U. Crystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs. Biochemistry, 51:7383-7392, 2012 Cited by PubMed: 22897232 DOI: 10.1021/bi300687g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation