4ERF
crystal structure of MDM2 (17-111) in complex with compound 29 (AM-8553)
Summary for 4ERF
Entry DOI | 10.2210/pdb4erf/pdb |
Related | 4ERE |
Descriptor | E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl}acetic acid (3 entities in total) |
Functional Keywords | mdm2, p53, protein protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 3 |
Total formula weight | 34903.38 |
Authors | Huang, X. (deposition date: 2012-04-20, release date: 2012-05-23, Last modification date: 2024-02-28) |
Primary citation | Rew, Y.,Sun, D.,Gonzalez-Lopez De Turiso, F.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Deignan, J.,Fox, B.M.,Gustin, D.,Huang, X.,Jiang, M.,Jiao, X.,Jin, L.,Kayser, F.,Kopecky, D.J.,Li, Y.,Lo, M.C.,Long, A.M.,Michelsen, K.,Oliner, J.D.,Osgood, T.,Ragains, M.,Saiki, A.Y.,Schneider, S.,Toteva, M.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Medina, J.C.,Olson, S.H. Structure-based design of novel inhibitors of the MDM2-p53 interaction. J.Med.Chem., 55:4936-4954, 2012 Cited by PubMed: 22524527DOI: 10.1021/jm300354j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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