4EMT
Crystal Structure of human STING bound to c-di-GMP
Summary for 4EMT
Entry DOI | 10.2210/pdb4emt/pdb |
Related | 4EMU |
Descriptor | Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, ... (4 entities in total) |
Functional Keywords | alpha/beta fold, innate immune sensor, c-di-gmp, c-di-amp, membrane protein |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: Q86WV6 |
Total number of polymer chains | 2 |
Total formula weight | 43966.38 |
Authors | |
Primary citation | Shu, C.,Yi, G.,Watts, T.,Kao, C.C.,Li, P. Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat.Struct.Mol.Biol., 19:722-724, 2012 Cited by PubMed: 22728658DOI: 10.1038/nsmb.2331 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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