4EMA

Human peroxisome proliferator-activated receptor gamma in complex with rosiglitazone

Summary for 4EMA

• Entry DOI: 10.2210/pdb4ema/pdb
• Related: 1PRG 1ZEO 2VV1 3DZU 3DZY 3GWX 4EM9
• Descriptor: Peroxisome proliferator-activated receptor gamma, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) (3 entities in total)
• Functional Keywords: nuclear receptor, retinoic acid receptor, nucleus, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P37231
• Total number of polymer chains: 2
• Total formula weight: 63178.40

Authors

Liberato, M.V.,Nascimento, A.S.,Polikarpov, I. (deposition date: 2012-04-11, release date: 2013-03-06, Last modification date: 2024-02-28)

• Primary citation: Liberato, M.V.,Nascimento, A.S.,Ayers, S.D.,Lin, J.Z.,Cvoro, A.,Silveira, R.L.,Martinez, L.,Souza, P.C.,Saidemberg, D.,Deng, T.,Amato, A.A.,Togashi, M.,Hsueh, W.A.,Phillips, K.,Palma, M.S.,Neves, F.A.,Skaf, M.S.,Webb, P.,Polikarpov, I.; Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists; Plos One, 7:e36297-e36297, 2012; PubMed: 22649490; DOI: 10.1371/journal.pone.0036297

Experimental method

X-RAY DIFFRACTION (2.545 Å)