4EKC

Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)

Summary for 4EKC

Entry DOI	10.2210/pdb4ekc/pdb
Related	1AGR 2AF0 2BCJ 2V4Z 4EKD
Descriptor	Guanine nucleotide-binding protein G(q) subunit alpha, Regulator of G-protein signaling 2, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	gtp-binding protein fold, regulator, g protein signaling, rgs, homology domain, gtpase activation, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Mus musculus (mouse) More
Cellular location	Nucleus: P21279 Isoform 1: Cell membrane. Isoform 2: Cell membrane. Isoform 3: Cell membrane. Isoform 4: Cell membrane: P41220
Total number of polymer chains	4
Total formula weight	114152.97
Authors	Tesmer, J.J.G.,Nance, M.R. (deposition date: 2012-04-09, release date: 2013-01-30, Last modification date: 2023-09-13)
Primary citation	Nance, M.R.,Kreutz, B.,Tesmer, V.M.,Sterne-Marr, R.,Kozasa, T.,Tesmer, J.J. Structural and functional analysis of the regulator of G protein signaling 2-g alpha q complex. Structure, 21:438-448, 2013 Cited by PubMed: 23434405 DOI: 10.1016/j.str.2012.12.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (7.4 Å)

Structure validation