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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4EKC

Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001501biological_processskeletal system development
A0001508biological_processaction potential
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007206biological_processphospholipase C-activating G protein-coupled glutamate receptor signaling pathway
A0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
A0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007218biological_processneuropeptide signaling pathway
A0007507biological_processheart development
A0008217biological_processregulation of blood pressure
A0009755biological_processhormone-mediated signaling pathway
A0009791biological_processpost-embryonic development
A0010543biological_processregulation of platelet activation
A0016020cellular_componentmembrane
A0016322biological_processneuron remodeling
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0021884biological_processforebrain neuron development
A0030234molecular_functionenzyme regulator activity
A0030425cellular_componentdendrite
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031965cellular_componentnuclear membrane
A0032024biological_processpositive regulation of insulin secretion
A0034695biological_processresponse to prostaglandin E
A0042711biological_processmaternal behavior
A0042733biological_processembryonic digit morphogenesis
A0043066biological_processnegative regulation of apoptotic process
A0043267biological_processnegative regulation of potassium ion transport
A0044297cellular_componentcell body
A0044877molecular_functionprotein-containing complex binding
A0045634biological_processregulation of melanocyte differentiation
A0046872molecular_functionmetal ion binding
A0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
A0048066biological_processdevelopmental pigmentation
A0050821biological_processprotein stabilization
A0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
A0060828biological_processregulation of canonical Wnt signaling pathway
A0071468biological_processcellular response to acidic pH
A0086100biological_processendothelin receptor signaling pathway
A0098793cellular_componentpresynapse
A0099524cellular_componentpostsynaptic cytosol
A0140582biological_processadenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
A1904888biological_processcranial skeletal system development
A1990806biological_processligand-gated ion channel signaling pathway
C0000166molecular_functionnucleotide binding
C0001501biological_processskeletal system development
C0001508biological_processaction potential
C0001664molecular_functionG protein-coupled receptor binding
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005096molecular_functionGTPase activator activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0005901cellular_componentcaveola
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007206biological_processphospholipase C-activating G protein-coupled glutamate receptor signaling pathway
C0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
C0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
C0007215biological_processglutamate receptor signaling pathway
C0007218biological_processneuropeptide signaling pathway
C0007507biological_processheart development
C0008217biological_processregulation of blood pressure
C0009755biological_processhormone-mediated signaling pathway
C0009791biological_processpost-embryonic development
C0010543biological_processregulation of platelet activation
C0016020cellular_componentmembrane
C0016322biological_processneuron remodeling
C0016787molecular_functionhydrolase activity
C0019001molecular_functionguanyl nucleotide binding
C0021884biological_processforebrain neuron development
C0030234molecular_functionenzyme regulator activity
C0030425cellular_componentdendrite
C0031683molecular_functionG-protein beta/gamma-subunit complex binding
C0031965cellular_componentnuclear membrane
C0032024biological_processpositive regulation of insulin secretion
C0034695biological_processresponse to prostaglandin E
C0042711biological_processmaternal behavior
C0042733biological_processembryonic digit morphogenesis
C0043066biological_processnegative regulation of apoptotic process
C0043267biological_processnegative regulation of potassium ion transport
C0044297cellular_componentcell body
C0044877molecular_functionprotein-containing complex binding
C0045634biological_processregulation of melanocyte differentiation
C0046872molecular_functionmetal ion binding
C0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
C0048066biological_processdevelopmental pigmentation
C0050821biological_processprotein stabilization
C0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
C0060828biological_processregulation of canonical Wnt signaling pathway
C0071468biological_processcellular response to acidic pH
C0086100biological_processendothelin receptor signaling pathway
C0098793cellular_componentpresynapse
C0099524cellular_componentpostsynaptic cytosol
C0140582biological_processadenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
C1904888biological_processcranial skeletal system development
C1990806biological_processligand-gated ion channel signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GDP A 400
ChainResidue
AGLU49
AVAL182
ACYS183
AASN274
ALYS275
AASP277
ALEU278
ACYS330
AALA331
ATHR332
AALF401
ASER50
AMG402
AHOH502
AHOH503
AGLY51
ALYS52
ASER53
ATHR54
ASER156
ALEU180
AARG181
site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ALF A 401
ChainResidue
AGLY48
AGLU49
ALYS52
APRO185
ATHR186
AGLY208
AGLN209
AGDP400
AMG402
AHOH501
AHOH502
AHOH503
site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 402
ChainResidue
ASER53
ATHR186
AGDP400
AALF401
AHOH502
AHOH503
site_idAC4
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GDP C 400
ChainResidue
CGLU49
CSER50
CGLY51
CLYS52
CSER53
CTHR54
CSER156
CLEU180
CARG181
CVAL182
CCYS183
CASN274
CLYS275
CASP277
CLEU278
CCYS330
CALA331
CTHR332
CALF401
CMG402
CHOH502
CHOH503
site_idAC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ALF C 401
ChainResidue
CGLY48
CGLU49
CLYS52
CPRO185
CTHR186
CGLY208
CGLN209
CGDP400
CMG402
CHOH501
CHOH502
CHOH503
site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG C 402
ChainResidue
CSER53
CTHR186
CGDP400
CALF401
CHOH502
CHOH503
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues26
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsRegion: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues18
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues14
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues10
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20966218","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7SQ2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20966218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SQ2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl histamine","evidences":[{"source":"PubMed","id":"23022564","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues232
DetailsDomain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues74
DetailsRegion: {"description":"Necessary to inhibit protein synthesis","evidences":[{"source":"PubMed","id":"19736320","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-11-05

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