4EKC
Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 347 | 40634.2 | 2 | UniProt (P21279) Pfam (PF00503) In PDB | Mus musculus (mouse) | Guanine nucleotide-binding protein alpha-q |
2 | B, D | Regulator of G-protein signaling 2 | polymer | 137 | 15871.8 | 2 | UniProt (P41220) Pfam (PF00615) In PDB | Homo sapiens (human) | RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8 |
3 | A, C | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
4 | A, C | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) | |||
5 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
6 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, C: 18 - 359 (UniProt: P21279)
B, D: 72 - 203 (UniProt: P41220)
PDB | External Database | Details |
---|---|---|
Gly 13 | - | expression tag |
Ala 14 | - | expression tag |
Met 15 | - | expression tag |
Gly 16 | - | expression tag |
Ser 17 | - | expression tag |
Asp 125 | Glu 125 | engineered mutation |
Val 126 | Asn 126 | engineered mutation |
Asp 128 | Tyr 128 | engineered mutation |
Tyr 129 | Val 129 | engineered mutation |
Ala 130 | Asp 130 | engineered mutation |
Cys 183 | Arg 183 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 67 | - | expression tag |
Glu 68 | - | expression tag |
Phe 69 | - | expression tag |
Gly 70 | - | expression tag |
Ser 71 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 113012.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1141.0 | |
All* | Total formula weight | 114153.0 |