4EJD

HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1 in the outside/top of flap

4EJD の概要

• エントリーDOI: 10.2210/pdb4ejd/pdb
• 関連するPDBエントリー: 4EJ8 4EJK 4EJL
• 関連するBIRD辞書のPRD_ID: PRD_000557
• 分子名称: Protease, pepstatin, BETA-MERCAPTOETHANOL, ... (6 entities in total)
• 機能のキーワード: apo protease, allostery, fragment binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12499
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 22837.21

構造登録者

Tiefenbrunn, T.,Stout, C.D. (登録日: 2012-04-06, 公開日: 2013-05-01, 最終更新日: 2014-02-19)

• 主引用文献: Tiefenbrunn, T.,Forli, S.,Baksh, M.M.,Chang, M.W.,Happer, M.,Lin, Y.C.,Perryman, A.L.,Rhee, J.K.,Torbett, B.E.,Olson, A.J.,Elder, J.H.,Finn, M.G.,Stout, C.D.; Small molecule regulation of protein conformation by binding in the Flap of HIV protease.; Acs Chem.Biol., 8:1223-1231, 2013; PubMed: 23540839; DOI: 10.1021/cb300611p

実験手法

X-RAY DIFFRACTION (1.103 Å)