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4EDZ

Crystal structure of hH-PGDS with water displacing inhibitor

Summary for 4EDZ
Entry DOI10.2210/pdb4edz/pdb
Related4EDY 4EE0
DescriptorHematopoietic prostaglandin D synthase, GLUTATHIONE, 4-(3-methylisoquinolin-1-yl)-N-[2-(morpholin-4-yl)ethyl]benzamide, ... (5 entities in total)
Functional Keywordsinhibitor, solvent replacement, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: O60760
Total number of polymer chains4
Total formula weight96022.61
Authors
Day, J.E.,Thorarensen, A.,Trujillo, J.I. (deposition date: 2012-03-27, release date: 2012-05-16, Last modification date: 2024-02-28)
Primary citationTrujillo, J.I.,Kiefer, J.R.,Huang, W.,Day, J.E.,Moon, J.,Jerome, G.M.,Bono, C.P.,Kornmeier, C.M.,Williams, M.L.,Kuhn, C.,Rennie, G.R.,Wynn, T.A.,Carron, C.P.,Thorarensen, A.
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.
Bioorg.Med.Chem.Lett., 22:3795-3799, 2012
Cited by
PubMed: 22546671
DOI: 10.1016/j.bmcl.2012.04.004
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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