4EDZ
Crystal structure of hH-PGDS with water displacing inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hematopoietic prostaglandin D synthase | polymer | 199 | 23310.7 | 4 | UniProt (O60760) Pfam (PF02798) Pfam (PF14497) | Homo sapiens (human) | H-PGDS, GST class-sigma, Glutathione S-transferase, Glutathione-dependent PGD synthase, Glutathione-requiring prostaglandin D synthase, Prostaglandin-H2 D-isomerase |
| 2 | E, H, K, M (A, B, C, D) | GLUTATHIONE | non-polymer | 307.3 | 4 | Chemie (GSH) | |||
| 3 | F, I, L, N (A, B, C, D) | 4-(3-methylisoquinolin-1-yl)-N-[2-(morpholin-4-yl)ethyl]benzamide | non-polymer | 375.5 | 4 | Chemie (0O5) | |||
| 4 | G, J (B, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 468 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 199 (UniProt: O60760)
| PDB | External Database | Details |
|---|---|---|
| Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 93242.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2779.8 | |
| All* | Total formula weight | 96022.6 |
