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4EDZ

Crystal structure of hH-PGDS with water displacing inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DHematopoietic prostaglandin D synthasepolymer19923310.74UniProt (O60760)
Pfam (PF02798)
Pfam (PF14497)
In PDB
Homo sapiens (human)H-PGDS, GST class-sigma, Glutathione S-transferase, Glutathione-dependent PGD synthase, Glutathione-requiring prostaglandin D synthase, Prostaglandin-H2 D-isomerase
2A, B, C, DGLUTATHIONEnon-polymer307.34Chemie (GSH)
3A, B, C, D4-(3-methylisoquinolin-1-yl)-N-[2-(morpholin-4-yl)ethyl]benzamidenon-polymer375.54Chemie (0O5)
4B, CMAGNESIUM IONnon-polymer24.32Chemie (MG)
5waterwater18.0468Chemie (HOH)
Sequence modifications
A, B, C, D: 2 - 199 (UniProt: O60760)
PDBExternal DatabaseDetails
Ala 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight93242.9
Non-Polymers*Number of molecules10
Total formula weight2779.8
All*Total formula weight96022.6
*Water molecules are not included.

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PDB entries from 2024-09-18

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