4E2J

X-Ray Crystal Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with mometasone furoate and TIF-2 coactivator fragment

Summary for 4E2J

Entry DOI	10.2210/pdb4e2j/pdb
Descriptor	Ancestral Glucocorticoid Receptor 2, Nuclear receptor coactivator 2, GLYCEROL, ... (6 entities in total)
Functional Keywords	nuclear receptor ligand binding domain, glucocorticoid receptor, steroid binding protein, hormone-hormone activator complex, hormone/hormone activator
Biological source	synthetic construct More
Cellular location	Nucleus: Q15596
Total number of polymer chains	4
Total formula weight	61751.29
Authors	Kohn, J.A.,Deshpande, K.,Ortlund, E.A. (deposition date: 2012-03-08, release date: 2012-03-28, Last modification date: 2023-09-13)
Primary citation	Kohn, J.A.,Deshpande, K.,Ortlund, E.A. Deciphering Modern Glucocorticoid Cross-pharmacology Using Ancestral Corticosteroid Receptors. J.Biol.Chem., 287:16267-16275, 2012 Cited by PubMed: 22437833 DOI: 10.1074/jbc.M112.346411 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation