4E2J
X-Ray Crystal Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with mometasone furoate and TIF-2 coactivator fragment
Summary for 4E2J
Entry DOI | 10.2210/pdb4e2j/pdb |
Descriptor | Ancestral Glucocorticoid Receptor 2, Nuclear receptor coactivator 2, GLYCEROL, ... (6 entities in total) |
Functional Keywords | nuclear receptor ligand binding domain, glucocorticoid receptor, steroid binding protein, hormone-hormone activator complex, hormone/hormone activator |
Biological source | synthetic construct More |
Cellular location | Nucleus: Q15596 |
Total number of polymer chains | 4 |
Total formula weight | 61751.29 |
Authors | Kohn, J.A.,Deshpande, K.,Ortlund, E.A. (deposition date: 2012-03-08, release date: 2012-03-28, Last modification date: 2023-09-13) |
Primary citation | Kohn, J.A.,Deshpande, K.,Ortlund, E.A. Deciphering Modern Glucocorticoid Cross-pharmacology Using Ancestral Corticosteroid Receptors. J.Biol.Chem., 287:16267-16275, 2012 Cited by PubMed: 22437833DOI: 10.1074/jbc.M112.346411 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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