4DPD
WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP
Summary for 4DPD
Entry DOI | 10.2210/pdb4dpd/pdb |
Related | 1J3I 2QGT 3DGA 4DDR 4DP3 4DPH |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, DIHYDROFOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | dhfr, rossmann fold, reductase, nadph binding, oxidoreductase, transferase |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 2 |
Total formula weight | 145459.18 |
Authors | Yuthavong, Y.,Vilaivan, T.,Kamchonwongpaisan, S.,Charman, S.A.,McLennan, D.N.,White, K.L.,Vivas, L.,Bongard, E.,Chitnumsub, P.,Tarnchompoo, B.,Thongphanchang, C.,Taweechai, S.,Vanichtanakul, J.,Arwon, U.,Fantauzzi, P.,Yuvaniyama, J.,Charman, W.N.,Matthews, D. (deposition date: 2012-02-13, release date: 2012-11-14, Last modification date: 2023-11-08) |
Primary citation | Yuthavong, Y.,Tarnchompoo, B.,Vilaivan, T.,Chitnumsub, P.,Kamchonwongpaisan, S.,Charman, S.A.,McLennan, D.N.,White, K.L.,Vivas, L.,Bongard, E.,Thongphanchang, C.,Taweechai, S.,Vanichtanankul, J.,Rattanajak, R.,Arwon, U.,Fantauzzi, P.,Yuvaniyama, J.,Charman, W.N.,Matthews, D. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target Proc.Natl.Acad.Sci.USA, 109:16823-16828, 2012 Cited by PubMed: 23035243DOI: 10.1073/pnas.1204556109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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