4DM8

Crystal structure of RARb LBD in complex with 9cis retinoic acid

Summary for 4DM8

Entry DOI	10.2210/pdb4dm8/pdb
Related	1XAP 4DM6 4DMA
Descriptor	Retinoic acid receptor beta, Nuclear receptor coactivator 1, RETINOIC ACID, ... (4 entities in total)
Functional Keywords	nuclear receptor, rarb, 9cis retinoic acid, alpha helical sandwich, transcription factor, retinoic acid, transcription-protein binding complex, transcription/protein binding
Biological source	Homo sapiens (human) More
Cellular location	Isoform Beta-1: Nucleus. Isoform Beta-2: Nucleus. Isoform Beta-4: Cytoplasm: P10826 Nucleus : Q15788
Total number of polymer chains	4
Total formula weight	66571.12
Authors	Osz, J.,Br livet, Y.,Peluso-Iltis, C.,Cura, V.,Eiler, S.,Ruff, M.,Bourguet, W.,Rochel, N.,Moras, D. (deposition date: 2012-02-07, release date: 2012-03-07, Last modification date: 2024-02-28)
Primary citation	Osz, J.,Brelivet, Y.,Peluso-Iltis, C.,Cura, V.,Eiler, S.,Ruff, M.,Bourguet, W.,Rochel, N.,Moras, D. Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors. Proc.Natl.Acad.Sci.USA, 109:E588-E594, 2012 Cited by PubMed: 22355136 DOI: 10.1073/pnas.1118192109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation