4DM8
Crystal structure of RARb LBD in complex with 9cis retinoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Retinoic acid receptor beta | polymer | 267 | 30179.0 | 2 | UniProt (P10826) Pfam (PF00104) | Homo sapiens (human) | RAR-beta, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon |
| 2 | C, D (C, D) | Nuclear receptor coactivator 1 | polymer | 25 | 2806.2 | 2 | UniProt (Q15788) Pfam (PF08832) | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
| 3 | E, F (A, B) | RETINOIC ACID | non-polymer | 300.4 | 2 | Chemie (REA) PubChem (5538) PubChem (444795) PubChem (449171) PubChem (5282379) PubChem (6336207) PubChem (6336229) PubChem (6419708) PubChem (6603983) PubChem (9796370) PubChem (9861147) PubChem (10881132) PubChem (12358677) PubChem (12358678) PubChem (12358679) PubChem (12358681) PubChem (23275881) PubChem (25145416) PubChem (445925) PubChem (87179195) PubChem (87519764) PubChem (87980058) PubChem (88439848) PubChem (88525859) PubChem (88604688) PubChem (134688661) PubChem (139597075) PubChem (145826768) PubChem (166478803) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A, B: 178 - 423 (UniProt: P10826)
| PDB | External Database | Details |
|---|---|---|
| Met 157 | - | initiating methionine |
| Gly 158 | - | expression tag |
| Ser 159 | - | expression tag |
| Ser 160 | - | expression tag |
| His 161 | - | expression tag |
| His 162 | - | expression tag |
| His 163 | - | expression tag |
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| His 166 | - | expression tag |
| Ser 167 | - | expression tag |
| Ser 168 | - | expression tag |
| Gly 169 | - | expression tag |
| Leu 170 | - | expression tag |
| Val 171 | - | expression tag |
| Pro 172 | - | expression tag |
| Arg 173 | - | expression tag |
| Gly 174 | - | expression tag |
| Ser 175 | - | expression tag |
| His 176 | - | expression tag |
| Met 177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 65970.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 600.9 | |
| All* | Total formula weight | 66571.1 |
