4DM6

Crystal structure of RARb LBD homodimer in complex with TTNPB

Summary for 4DM6

• Entry DOI: 10.2210/pdb4dm6/pdb
• Related: 1XAP 4DM8 4DMA
• Descriptor: Retinoic acid receptor beta, Nuclear receptor coactivator 1, 4-[(1E)-2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PROP-1-ENYL]BENZOIC ACID, ... (4 entities in total)
• Functional Keywords: transcription, nuclear receptor, retinoic acid, alpha helical sandwich, transcription regulator, retinoic acid binding, nucleus - cytoplasm, transcription-protein binding complex, transcription/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform Beta-1: Nucleus. Isoform Beta-2: Nucleus. Isoform Beta-4: Cytoplasm: P10826; Nucleus (By similarity): Q15788
• Total number of polymer chains: 4
• Total formula weight: 66667.20

Authors

Osz, J.,Brelivet, Y.,Peluso-Iltis, C.,Cura, V.,Eiler, S.,Ruff, M.,Bourguet, W.,Rochel, N.,Moras, D. (deposition date: 2012-02-07, release date: 2012-03-07, Last modification date: 2024-02-28)

• Primary citation: Osz, J.,Brelivet, Y.,Peluso-Iltis, C.,Cura, V.,Eiler, S.,Ruff, M.,Bourguet, W.,Rochel, N.,Moras, D.; Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.; Proc.Natl.Acad.Sci.USA, 109:E588-E594, 2012; PubMed: 22355136; DOI: 10.1073/pnas.1118192109

Experimental method

X-RAY DIFFRACTION (1.9 Å)