4C9R

Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form I

4C9R の概要

• エントリーDOI: 10.2210/pdb4c9r/pdb
• 関連するPDBエントリー: 4C84 4C85 4C86 4C8A 4C8C 4C8F 4C8P 4C8T 4C8U 4C8V 4C8W 4C99 4C9A 4C9E 4C9U 4C9V
• 分子名称: E3 UBIQUITIN-PROTEIN LIGASE ZNRF3, R-SPONDIN-2 (3 entities in total)
• 機能のキーワード: ligase-signaling protein complex, wnt, rnf43, lgr4, lgr5, lgr6, rspo, r-spondin, r-spo, rspo1, rspo3, rspo4, receptor, membrane, signalling, ligase/signaling protein
• 由来する生物種: XENOPUS (SILURANA) TROPICALIS (WESTERN CLAWED FROG); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein (By similarity): Q08D68; Secreted (By similarity): Q5M7L6
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 68551.53

構造登録者

Zebisch, M.,Jones, E.Y. (登録日: 2013-10-02, 公開日: 2013-11-20, 最終更新日: 2013-11-27)

• 主引用文献: Zebisch, M.,Xu, Y.,Krastev, C.,Macdonald, B.T.,Chen, M.,Gilbert, R.J.C.,He, X.,Jones, E.Y.; Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin.; Nat.Commun., 4:2787-, 2013; PubMed: 24225776; DOI: 10.1038/NCOMMS3787

実験手法

X-RAY DIFFRACTION (2.1 Å)