4C9U

Xenopus ZNRF3 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2 crystal form II

Summary for 4C9U

Entry DOI	10.2210/pdb4c9u/pdb
Related	4C84 4C85 4C86 4C8A 4C8C 4C8F 4C8P 4C8T 4C8U 4C8V 4C8W 4C99 4C9A 4C9E 4C9R 4C9V
Descriptor	E3 UBIQUITIN-PROTEIN LIGASE ZNRF3, R-SPONDIN-2 (2 entities in total)
Functional Keywords	ligase-signaling protein complex, wnt, rnf43, lgr4, lgr5, lgr6, rspo, r-spondin, r-spo, rspo1, rspo3, rspo4, receptor, membrane, signalling, ligase/signaling protein
Biological source	XENOPUS (SILURANA) TROPICALIS (WESTERN CLAWED FROG) More
Cellular location	Cell membrane; Single-pass type I membrane protein (By similarity): Q08D68 Secreted (By similarity): Q5M7L6
Total number of polymer chains	4
Total formula weight	68551.53
Authors	Zebisch, M.,Jones, E.Y. (deposition date: 2013-10-03, release date: 2013-11-20, Last modification date: 2013-11-27)
Primary citation	Zebisch, M.,Xu, Y.,Krastev, C.,Macdonald, B.T.,Chen, M.,Gilbert, R.J.C.,He, X.,Jones, E.Y. Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. Nat.Commun., 4:2787-, 2013 Cited by PubMed: 24225776 DOI: 10.1038/NCOMMS3787 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation