4BPM
Crystal structure of a human integral membrane enzyme
Summary for 4BPM
Entry DOI | 10.2210/pdb4bpm/pdb |
Related | 4BPD |
Descriptor | PROSTAGLANDIN E SYNTHASE, FUSION PEPTIDE, GLUTATHIONE, 2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide, ... (4 entities in total) |
Functional Keywords | isomerase, cancer, drug target, in meso crystallization, inflammation, inhibitor, leukotriene c4 synthase, lipid metabolism, membrane-associated proteins in eicosanoid and glutathione metabolism, mapag, membrane protein, mpges1, pain, microcrystal, anomalous dispersion, sulfur-sad, s-sad |
Biological source | HOMO SAPIENS More |
Total number of polymer chains | 1 |
Total formula weight | 21286.73 |
Authors | Li, D.,Wang, M.,Olieric, V.,Caffrey, M. (deposition date: 2013-05-27, release date: 2014-04-16, Last modification date: 2024-05-08) |
Primary citation | Li, D.,Howe, N.,Dukkipati, A.,Shah, S.T.A.,Bax, B.D.,Edge, C.,Bridges, A.,Hardwicke, P.,Singh, O.M.P.,Giblin, G.,Pautsch, A.,Pfau, R.,Schnapp, G.,Wang, M.,Olieric, V.,Caffrey, M. Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy. Cryst.Growth Des., 14:2034-, 2014 Cited by PubMed: 24803849DOI: 10.1021/CG500157X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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