4BPM
Crystal structure of a human integral membrane enzyme
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001516 | biological_process | prostaglandin biosynthetic process |
A | 0004364 | molecular_function | glutathione transferase activity |
A | 0004602 | molecular_function | glutathione peroxidase activity |
A | 0004667 | molecular_function | prostaglandin-D synthase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005641 | cellular_component | nuclear envelope lumen |
A | 0005737 | cellular_component | cytoplasm |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0006693 | biological_process | prostaglandin metabolic process |
A | 0007165 | biological_process | signal transduction |
A | 0008283 | biological_process | cell population proliferation |
A | 0008285 | biological_process | negative regulation of cell population proliferation |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016740 | molecular_function | transferase activity |
A | 0016853 | molecular_function | isomerase activity |
A | 0019233 | biological_process | sensory perception of pain |
A | 0031620 | biological_process | regulation of fever generation |
A | 0032308 | biological_process | positive regulation of prostaglandin secretion |
A | 0043295 | molecular_function | glutathione binding |
A | 0048471 | cellular_component | perinuclear region of cytoplasm |
A | 0050220 | molecular_function | prostaglandin-E synthase activity |
A | 0050727 | biological_process | regulation of inflammatory response |
A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE GSH A 1172 |
Chain | Residue |
A | ALA31 |
A | TYR117 |
A | ARG126 |
A | SER127 |
A | TYR130 |
A | LVJ1173 |
A | HOH2004 |
A | HOH2024 |
A | HOH2037 |
A | THR34 |
A | ARG38 |
A | LEU69 |
A | ARG70 |
A | ARG73 |
A | ASN74 |
A | GLU77 |
A | HIS113 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE LVJ A 1173 |
Chain | Residue |
A | GLY35 |
A | GLN36 |
A | LEU39 |
A | ASP49 |
A | ARG52 |
A | HIS53 |
A | ALA123 |
A | PRO124 |
A | SER127 |
A | VAL128 |
A | THR131 |
A | LEU132 |
A | GSH1172 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 108 |
Details | TRANSMEM: Helical => ECO:0000305|PubMed:23431194 |
Chain | Residue | Details |
A | LEU13-LYS41 | |
A | SER61-SER90 | |
A | PRO96-GLY119 | |
A | PRO124-PHE152 |
site_id | SWS_FT_FI2 |
Number of Residues | 21 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:23431194 |
Chain | Residue | Details |
A | LYS42-ARG60 | |
A | LYS120-ALA123 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | TOPO_DOM: Lumenal => ECO:0000305|PubMed:23431194 |
Chain | Residue | Details |
A | PHE91-ASN95 |
site_id | SWS_FT_FI4 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18682561, ECO:0000269|PubMed:23431194, ECO:0007744|PDB:4AL0, ECO:0007744|PDB:4BPM, ECO:0007744|PDB:4WAB, ECO:0007744|PDB:4YK5, ECO:0007744|PDB:4YL0, ECO:0007744|PDB:4YL1, ECO:0007744|PDB:4YL3, ECO:0007744|PDB:5BQG, ECO:0007744|PDB:5BQH, ECO:0007744|PDB:5BQI, ECO:0007744|PDB:5K0I, ECO:0007744|PDB:5T36, ECO:0007744|PDB:5T37, ECO:0007744|PDB:5TL9 |
Chain | Residue | Details |
A | ARG38 | |
A | ARG73 | |
A | HIS113 | |
A | TYR117 | |
A | ARG126 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: Essential for protaglandin-E synthase activity => ECO:0000269|PubMed:26755582, ECO:0000269|PubMed:27684486 |
Chain | Residue | Details |
A | ASP49 | |
A | ARG126 |