4BPM

Crystal structure of a human integral membrane enzyme

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	PROSTAGLANDIN E SYNTHASE, FUSION PEPTIDE	polymer	178	20360.9	1	UniProt (O14684) Pfam (PF01124) UniProt (by SIFTS) (Q16873) In PDB	HOMO SAPIENS	MICROSOMAL GLUTATHIONE S-TRANSFERASE 1-LIKE 1, MGST1-L1, MICROSOMAL PROSTAGLANDIN E SYNTHASE 1, MPGES-1, P53-INDUCED GENE 12 PROTEIN, PROSTAGLANDIN E2 SYNTHASE 1
2	A	GLUTATHIONE	non-polymer		307.3	1	Chemie (GSH)
3	A	2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide	non-polymer		618.5	1	Chemie (LVJ)
4		water	water		18.0	37	Chemie (HOH)

Sequence modifications

A: 10 - 152 (UniProt: O14684)

PDB	External Database	Details
Met 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
Phe 152	Leu 152	engineered mutation

A: 153 - 180 (PDB: 4BPM)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	20360.9
Non-Polymers*	Number of molecules	2
	Total formula weight	925.8
All*	Total formula weight	21286.7

*Water molecules are not included.