4BPM

Crystal structure of a human integral membrane enzyme

Summary for 4BPM

Entry DOI	10.2210/pdb4bpm/pdb
Related	4BPD
Descriptor	PROSTAGLANDIN E SYNTHASE, FUSION PEPTIDE, GLUTATHIONE, 2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide, ... (4 entities in total)
Functional Keywords	isomerase, cancer, drug target, in meso crystallization, inflammation, inhibitor, leukotriene c4 synthase, lipid metabolism, membrane-associated proteins in eicosanoid and glutathione metabolism, mapag, membrane protein, mpges1, pain, microcrystal, anomalous dispersion, sulfur-sad, s-sad
Biological source	HOMO SAPIENS More
Total number of polymer chains	1
Total formula weight	21286.73
Authors	Li, D.,Wang, M.,Olieric, V.,Caffrey, M. (deposition date: 2013-05-27, release date: 2014-04-16, Last modification date: 2019-04-03)
Primary citation	Li, D.,Howe, N.,Dukkipati, A.,Shah, S.T.A.,Bax, B.D.,Edge, C.,Bridges, A.,Hardwicke, P.,Singh, O.M.P.,Giblin, G.,Pautsch, A.,Pfau, R.,Schnapp, G.,Wang, M.,Olieric, V.,Caffrey, M. Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy. Cryst.Growth Des., 14:2034-, 2014 Cited by PubMed: 24803849 DOI: 10.1021/CG500157X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation