4BKU

Enoyl-ACP reductase FabI from Burkholderia pseudomallei with cofactor NADH and inhibitor PT155

Summary for 4BKU

Entry DOI	10.2210/pdb4bku/pdb
Related	4BKO 4BKQ 4BKR
Descriptor	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 5-(4-amino-2-methylphenoxy)-2-hexyl-4-hydroxy-1-methylpyridinium, ... (4 entities in total)
Functional Keywords	oxidoreductase, fatty acid biosynthesis, enoyl- acp reductase, pyridone
Biological source	BURKHOLDERIA PSEUDOMALLEI
Total number of polymer chains	1
Total formula weight	30305.25
Authors	Hirschbeck, M.W.,Liu, N.,Neckles, C.,Tonge, P.J.,Kisker, C. (deposition date: 2013-04-29, release date: 2014-04-09, Last modification date: 2023-12-20)
Primary citation	Schiebel, J.,Chang, A.,Shah, S.,Lu, Y.,Liu, L.,Pan, P.,Hirschbeck, M.W.,Tareilus, M.,Eltschkner, S.,Yu, W.,Cummings, J.E.,Knudson, S.E.,Bommineni, G.R.,Walker, S.G.,Slayden, R.A.,Sotriffer, C.A.,Tonge, P.J.,Kisker, C. Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (Acp) Reductase Inhibitor. J.Biol.Chem., 289:15987-, 2014 Cited by PubMed: 24739388 DOI: 10.1074/JBC.M113.532804 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.841 Å)

Structure validation