4B7I

Crystal Structure of Human IgG Fc Bearing Hybrid-type Glycans

Summary for 4B7I

• Entry DOI: 10.2210/pdb4b7i/pdb
• Related: 1AJ7 1AQK 1BEY 1D5B 1D5I 1D6V 1DN2 1E4K 1FC1 1FC2 1FCC 1H3T 1H3U 1H3V 1H3W 1H3Y 1I7Z 1L6X 1OQX 1T83 1T89 2IWG 2J6E 2RCS 2WAH 4ACP
• Descriptor: IG GAMMA-1 CHAIN C REGION, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: immune system, igg, antibody, swainsonine, hybrid
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 51052.66

Authors

Bowden, T.A.,Baruah, K.,Coles, C.H.,Harvey, D.J.,Song, B.D.,Stuart, D.I.,Aricescu, A.R.,Scanlan, C.N.,Jones, E.Y.,Crispin, M. (deposition date: 2012-08-20, release date: 2012-10-17, Last modification date: 2023-12-20)

• Primary citation: Bowden, T.A.,Baruah, K.,Coles, C.H.,Harvey, D.J.,Yu, X.,Song, B.D.,Stuart, D.I.,Aricescu, A.R.,Scanlan, C.N.,Jones, E.Y.,Crispin, M.; Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped During Glycan Biosynthesis.; J.Am.Chem.Soc., 134:17554-, 2012; PubMed: 23025485; DOI: 10.1021/JA306068G

Experimental method

X-RAY DIFFRACTION (2.36 Å)