2J6E

Crystal Structure of an Autoimmune Complex between a Human IgM Rheumatoid Factor and IgG1 Fc reveals a Novel Fc Epitope and Evidence for Affinity Maturation

Summary for 2J6E

• Entry DOI: 10.2210/pdb2j6e/pdb
• Related: 1AJ7 1AQK 1D5B 1D5I 1D6V 1DN2 1E4K 1FC1 1FC2 1FCC 1H3T 1H3U 1H3V 1H3W 1H3Y 1HZH 1I7Z 1IIS 1IIX 1L6X 1N7M 1OQX 1T83 2IWG 2RCS
• Descriptor: IG GAMMA-1 CHAIN C REGION, IGM, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: autoimmune complex human igm rheumatoid factor igg1-fc, immunoglobulin c region, membrane, glycoprotein, transmembrane, hypothetical protein, immune system, immunoglobulin domain
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 6
• Total formula weight: 156036.73

Authors

Duquerroy, S.,Stura, E.A.,Bressanelli, S.,Browne, H.,Beale, D.,Hamon, M.,Casali, P.,Vaney, M.C.,Rey, F.A.,Sutton, B.J.,Taussig, M.J. (deposition date: 2006-09-28, release date: 2007-04-10, Last modification date: 2023-12-13)

• Primary citation: Duquerroy, S.,Stura, E.A.,Bressanelli, S.,Fabiane, S.M.,Vaney, M.C.,Beale, D.,Hamon, M.,Casali, P.,Rey, F.A.,Sutton, B.J.,Taussig, M.J.; Crystal structure of a human autoimmune complex between IgM rheumatoid factor RF61 and IgG1 Fc reveals a novel epitope and evidence for affinity maturation.; J.Mol.Biol., 368:1321-1331, 2007; PubMed: 17395205; DOI: 10.1016/j.jmb.2007.02.085

Experimental method

X-RAY DIFFRACTION (3 Å)