2J6E
Crystal Structure of an Autoimmune Complex between a Human IgM Rheumatoid Factor and IgG1 Fc reveals a Novel Fc Epitope and Evidence for Affinity Maturation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | IG GAMMA-1 CHAIN C REGION | polymer | 232 | 26140.6 | 2 | UniProt (P01857) Pfam (PF07654) In PDB | HOMO SAPIENS (HUMAN) | IGG1 |
2 | H, I | IGM | polymer | 231 | 24831.9 | 2 | HOMO SAPIENS (HUMAN) | FAB HEAVY CHAIN | |
3 | L, M | IGM | polymer | 234 | 24757.7 | 2 | HOMO SAPIENS (HUMAN) | FAB LIGHT CHAIN | |
4 | C, D | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 2 | In PDB GlyTouCan (G19282BU) | |||
5 | A | CADMIUM ION | non-polymer | 112.4 | 1 | Chemie (CD) | |||
6 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
7 | A | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
8 | A, B, M | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 6 | Chemie (MPD) | |||
9 | A, B, H | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
10 | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A, B: 216 - 447 (UniProt: P01857)
PDB | External Database | Details |
---|---|---|
Glu 270 | Asp 153 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 151460.3 | |
Branched | Number of molecules | 2 |
Total formula weight | 3251.0 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 1325.4 | |
All* | Total formula weight | 156036.7 |