4AWI

Human Jnk1alpha kinase with 4-phenyl-7-azaindole IKK2 inhibitor.

Summary for 4AWI

• Entry DOI: 10.2210/pdb4awi/pdb
• Related: 1UKH 1UKI 2GMX 2H96 2XRW 2XS0
• Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE 8, N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-4-[2-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS
• Cellular location: Cytoplasm: P45983
• Total number of polymer chains: 1
• Total formula weight: 43147.89

Authors

Chung, C.,Vicentini, G.,Liddle, J.,Bamborough, P. (deposition date: 2012-06-03, release date: 2013-05-01, Last modification date: 2024-05-08)

Primary citation

Liddle, J.,Bamborough, P.,Barker, M.D.,Campos, S.,Chung, C.,Cousins, R.P.C.,Faulder, P.,Heathcote, M.L.,Hobbs, H.,Holmes, D.S.,Ioannou, C.,Ramirez-Molina, C.,Morse, M.A.,Osborn, R.,Payne, J.J.,Pritchard, J.M.,Rumsey, W.L.,Tape, D.T.,Vicentini, G.,Whitworth, C.,Williamson, R.A.
4-Phenyl-7-Azaindoles as Potent, Selective and Bioavailable Ikk2 Inhibitors Demonstrating Good in Vivo Efficacy.
Bioorg.Med.Chem.Lett., 22:5222-, 2012

PubMed Abstract: The lead optimization of a series of potent azaindole IKK2 inhibitors is described. Optimization of the human whole blood activity and selectivity over IKK1 in parallel led to the discovery of 16, a potent and selective IKK2 inhibitor showing good efficacy in a rat model of neutrophil activation.

PubMed: 22801646
DOI: 10.1016/J.BMCL.2012.06.065

Experimental method

X-RAY DIFFRACTION (1.91 Å)