4AWI
Human Jnk1alpha kinase with 4-phenyl-7-azaindole IKK2 inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MITOGEN-ACTIVATED PROTEIN KINASE 8 | polymer | 369 | 42508.2 | 1 | UniProt (P45983) Pfam (PF00069) | HOMO SAPIENS | MAP KINASE 8, MAPK 8, JNK-46, STRESS-ACTIVATED PROTEIN KINASE 1C, SAPK1C, STRESS-ACTIVATED PROTEIN KINASE JNK1, C- JUN N-TERMINAL KINASE 1 |
| 2 | B (A) | N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-4-[2-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide | non-polymer | 447.6 | 1 | Chemie (AQ2) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (A) | water | water | 18.0 | 286 | Chemie (HOH) |
Sequence modifications
A: 1 - 364 (UniProt: P45983)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42508.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 639.7 | |
| All* | Total formula weight | 43147.9 |
