4ASF

The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90

4ASF の概要

• エントリーDOI: 10.2210/pdb4asf/pdb
• 関連するPDBエントリー: 4AS9 4ASA 4ASB 4ASG
• 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (8S,9R,13R,14S,16R)-21-(furan-2-yl)-13-hydroxy-8,14,19-trimethoxy-16-methyl-4,10,12-trimethylidene-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),18-dien-9-yl carbamate, NICKEL (II) ION, ... (4 entities in total)
• 機能のキーワード: inhibition, ansamycin, chaperone
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25676.17

構造登録者

Roe, S.M.,Prodromou, C. (登録日: 2012-05-01, 公開日: 2013-04-03, 最終更新日: 2024-05-01)

• 主引用文献: Kitson, R.R.,Chang, C.H.,Xiong, R.,Williams, H.E.,Davis, A.L.,Lewis, W.,Dehn, D.L.,Siegel, D.,Roe, S.M.,Prodromou, C.,Ross, D.,Moody, C.J.; Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.; Nat Chem, 5:307-314, 2013; PubMed: 23511419; DOI: 10.1038/nchem.1596

実験手法

X-RAY DIFFRACTION (2.6 Å)