4AS0
Cyclometalated Phthalimides as Protein Kinase Inhibitors
Summary for 4AS0
Entry DOI | 10.2210/pdb4as0/pdb |
Related | 1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 4A7C 4ALU 4ALV 4ALW |
Descriptor | SERINE/THREONINE-PROTEIN KINASE PIM-1, PHTALIMIDE-RUTHENIUM COMPLEX (3 entities in total) |
Functional Keywords | transferase, pim1, octasporine, ruthenium, kinase inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 31950.29 |
Authors | Blanck, S.,Geisselbrecht, Y.,Middel, S.,Mietke, T.,Harms, K.,Essen, L.-O.,Meggers, E. (deposition date: 2012-04-27, release date: 2012-10-03, Last modification date: 2023-12-20) |
Primary citation | Blanck, S.,Geisselbrecht, Y.,Kraling, K.,Middel, S.,Mietke, T.,Harms, K.,Essen, L.-O.,Meggers, E. Bioactive Cyclometalated Phthalimides: Design, Synthesis and Kinase Inhibition. Dalton Trans, 41:9337-, 2012 Cited by PubMed: 22733119DOI: 10.1039/C2DT30940H PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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