4AEL
PDE10A in complex with the inhibitor AZ5
Summary for 4AEL
Entry DOI | 10.2210/pdb4ael/pdb |
Related | 1LRB 2WEY 2Y0J 2Y5U 2Y5V 2Y5X |
Descriptor | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase, hit-to-lead, enzyme inhibitor, naphtyridine |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 79844.66 |
Authors | Bauer, U.,Giordanetto, F.,Bauer, M.,OMahony, G.,Johansson, K.E.,Knecht, W.,Hartleib-Geschwindner, J.,Toppner Carlsson, E.,Enroth, C.,Sjogren, T. (deposition date: 2012-01-11, release date: 2012-01-25, Last modification date: 2023-12-20) |
Primary citation | Bauer, U.,Giordanetto, F.,Bauer, M.,O'Mahony, G.,Johansson, K.E.,Knecht, W.,Hartleib-Geschwindner, J.,Carlsson, E.T.,Enroth, C. Discovery of 4-Hydroxy-1,6-Naphthyridine-3-Carbonitrile Derivatives as Novel Pde10A Inhibitors. Bioorg.Med.Chem.Lett., 22:1944-, 2012 Cited by PubMed: 22321214DOI: 10.1016/J.BMCL.2012.01.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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