Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4A9T

CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR

Summary for 4A9T
Entry DOI10.2210/pdb4a9t/pdb
Related1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 4A9R 4A9S 4A9U
DescriptorSERINE/THREONINE-PROTEIN KINASE CHK2, 2-(4-{[1-(4-CHLOROBENZYL)PIPERIDIN-4-YL]METHOXY}PHENYL)-1H-BENZIMIDAZOLE-5-CARBOXAMIDE, NITRATE ION, ... (5 entities in total)
Functional Keywordstransferase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
Total number of polymer chains1
Total formula weight37835.03
Authors
Matijssen, C.,Silva-Santisteban, M.C.,Westwood, I.M.,Siddique, S.,Choi, V.,Sheldrake, P.,van Montfort, R.L.M.,Blagg, J. (deposition date: 2011-11-28, release date: 2012-10-10, Last modification date: 2023-12-20)
Primary citationMatijssen, C.,Silva-Santisteban, M.C.,Westwood, I.M.,Siddique, S.,Choi, V.,Sheldrake, P.,Van Montfort, R.L.M.,Blagg, J.
Benzimidazole Inhibitors of the Protein Kinase Chk2: Clarification of the Binding Mode by Flexible Side Chain Docking and Protein-Ligand Crystallography.
Bioorg.Med.Chem., 20:6630-, 2012
Cited by
PubMed: 23058106
DOI: 10.1016/J.BMC.2012.09.024
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon