4A9S

CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR

4A9S の概要

• エントリーDOI: 10.2210/pdb4a9s/pdb
• 関連するPDBエントリー: 1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 4A9R 4A9T 4A9U
• 分子名称: SERINE/THREONINE-PROTEIN KINASE CHK2, NITRATE ION, 2-(4-(3-HYDROXYPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXAMIDE, ... (4 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37519.20

構造登録者

Matijssen, C.,Silva-Santisteban, M.C.,Westwood, I.M.,Siddique, S.,Choi, V.,Sheldrake, P.,van Montfort, R.L.M.,Blagg, J. (登録日: 2011-11-28, 公開日: 2012-10-10, 最終更新日: 2023-12-20)

• 主引用文献: Matijssen, C.,Silva-Santisteban, M.C.,Westwood, I.M.,Siddique, S.,Choi, V.,Sheldrake, P.,Van Montfort, R.L.M.,Blagg, J.; Benzimidazole Inhibitors of the Protein Kinase Chk2: Clarification of the Binding Mode by Flexible Side Chain Docking and Protein-Ligand Crystallography.; Bioorg.Med.Chem., 20:6630-, 2012; PubMed: 23058106; DOI: 10.1016/J.BMC.2012.09.024

実験手法

X-RAY DIFFRACTION (2.66 Å)