4A9L
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1,3-DIMETHYL-6-(MORPHOLINE- 4-SULFONYL)-1,2,3,4-TETRAHYDROQUINAZOLIN-2-ONE
Summary for 4A9L
| Entry DOI | 10.2210/pdb4a9l/pdb |
| Related | 2YEL 2YEM 3ZYU 4A9E 4A9F 4A9H 4A9I 4A9J 4A9K |
| Descriptor | BROMODOMAIN-CONTAINING PROTEIN 4, 1,2-ETHANEDIOL, 1,3-dimethyl-6-(morpholin-4-ylsulfonyl)-3,4-dihydroquinazolin-2(1H)-one, ... (5 entities in total) |
| Functional Keywords | inhibitor, histone, epigenetic reader, signaling protein |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Nucleus (By similarity): O60885 |
| Total number of polymer chains | 1 |
| Total formula weight | 15734.98 |
| Authors | Chung, C.W.,Bamborough, P. (deposition date: 2011-11-26, release date: 2012-01-11, Last modification date: 2012-02-08) |
| Primary citation | Chung, C.W.,Dean, A.W.,Woolven, J.M.,Bamborough, P. Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55:576-, 2012 Cited by PubMed: 22136404DOI: 10.1021/JM201320W PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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