2YEL

Crystal Structure of the First Bromodomain of Human Brd4 with the inhibitor GW841819X

Summary for 2YEL

Entry DOI	10.2210/pdb2yel/pdb
Related	2YEK 2YEM
Descriptor	HUMAN BRD4, 1,2-ETHANEDIOL, BENZYL [(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE, ... (4 entities in total)
Functional Keywords	signaling protein, histone, epigenetic reader
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus (By similarity): O60885
Total number of polymer chains	1
Total formula weight	15584.91
Authors	Chung, C.W. (deposition date: 2011-03-25, release date: 2011-06-15, Last modification date: 2023-12-20)
Primary citation	Chung, C.W.,Coste, H.,White, J.H.,Mirguet, O.,Wilde, J.,Gosmini, R.L.,Delves, C.,Magny, S.M.,Woodward, R.,Hughes, S.A.,Boursier, E.V.,Flynn, H.,Bouillot, A.M.,Bamborough, P.,Brusq, J.M.,Gellibert, F.J.,Jones, E.J.,Riou, A.M.,Homes, P.,Martin, S.L.,Uings, I.J.,Toum, J.,Clement, C.A.,Boullay, A.B.,Grimley, R.L.,Blandel, F.M.,Prinjha, R.K.,Lee, K.,Kirilovsky, J.,Nicodeme, E. Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains. J.Med.Chem., 54:3827-, 2011 Cited by PubMed: 21568322 DOI: 10.1021/JM200108T PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation