2YEM

Crystal Structure of the Second Bromodomain of Human Brd4 with the inhibitor GW841819X

Summary for 2YEM

Entry DOI	10.2210/pdb2yem/pdb
Related	2YEK 2YEL
Descriptor	BROMODOMAIN-CONTAINING PROTEIN 4, BENZYL [(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE (3 entities in total)
Functional Keywords	signaling protein, histone, epigenetic reader
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	30967.60
Authors	Chung, C.W. (deposition date: 2011-03-25, release date: 2011-06-15, Last modification date: 2023-12-20)
Primary citation	Chung, C.W.,Coste, H.,White, J.H.,Mirguet, O.,Wilde, J.,Gosmini, R.L.,Delves, C.,Magny, S.M.,Woodward, R.,Hughes, S.A.,Boursier, E.V.,Flynn, H.,Bouillot, A.M.,Bamborough, P.,Brusq, J.M.,Gellibert, F.J.,Jones, E.J.,Riou, A.M.,Homes, P.,Martin, S.L.,Uings, I.J.,Toum, J.,Clement, C.A.,Boullay, A.B.,Grimley, R.L.,Blandel, F.M.,Prinjha, R.K.,Lee, K.,Kirilovsky, J.,Nicodeme, E. Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains. J.Med.Chem., 54:3827-, 2011 Cited by PubMed: 21568322 DOI: 10.1021/JM200108T PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation