2YEM
Crystal Structure of the Second Bromodomain of Human Brd4 with the inhibitor GW841819X
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | BROMODOMAIN-CONTAINING PROTEIN 4 | polymer | 130 | 15060.3 | 2 | UniProt (O60885) Pfam (PF00439) In PDB | HOMO SAPIENS (HUMAN) | PROTEIN HUNK1 |
2 | A, B | BENZYL [(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE | non-polymer | 423.5 | 2 | Chemie (WSH) | |||
3 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A, B: 333 - 460 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Ser 331 | - | expression tag |
Met 332 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 30120.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 846.9 | |
All* | Total formula weight | 30967.6 |