4A7G

Structure of human I113T SOD1 mutant complexed with 4-methylpiperazin- 1-yl)quinazoline in the p21 space group.

4A7G の概要

• エントリーDOI: 10.2210/pdb4a7g/pdb
• 関連するPDBエントリー: 1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 4SOD
• 分子名称: SUPEROXIDE DISMUTASE [CU-ZN], SULFATE ION, 4-(4-METHYLPIPERAZIN-1-YL)QUINAZOLINE, ... (8 entities in total)
• 機能のキーワード: oxidoreductase, amyotrophic lateral sclerosis, antioxidant, disease mutation, metal-binding, zn superoxide dismutase
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33101.11

構造登録者

Wright, G.S.A.,Kershaw, N.M.,Sharma, R.,Antonyuk, S.V.,Strange, R.W.,Berry, N.G.,O'Neil, P.M.,Hasnain, S.S. (登録日: 2011-11-14, 公開日: 2012-10-24, 最終更新日: 2019-10-09)

• 主引用文献: Kershaw, N.M.,Wright, G.S.,Sharma, R.,Antonyuk, S.V.,Strange, R.W.,Berry, N.G.,O'Neill, P.M.,Hasnain, S.S.; X-ray crystallography and computational docking for the detection and development of protein-ligand interactions.; Curr.Med.Chem., 20:569-575, 2013; PubMed: 23278398; DOI: 10.2174/0929867311320040008

実験手法

X-RAY DIFFRACTION (1.24 Å)