2VR8

Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.36 A resolution

Summary for 2VR8

• Entry DOI: 10.2210/pdb2vr8/pdb
• Related: 1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2V0A 2VR6 2VR7 4SOD
• Descriptor: SUPEROXIDE DISMUTASE [CU-ZN], COPPER (II) ION, ZINC ION, ... (6 entities in total)
• Functional Keywords: zinc, copper, human cu, cytoplasm, acetylation, ubl conjugation, disease mutation, zn superoxide dismutase, amyotrophic lateral sclerosis, antioxidant, metal-binding, oxidoreductase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: P00441
• Total number of polymer chains: 2
• Total formula weight: 32883.48

Authors

Antonyuk, S.,Cao, X.,Seetharaman, S.V.,Whitson, L.J.,Taylor, A.B.,Holloway, S.P.,Strange, R.W.,Doucette, P.A.,Tiwari, A.,Hayward, L.J.,Padua, S.,Cohlberg, J.A.,Selverstone Valentine, J.,Hasnain, S.S.,Hart, P.J. (deposition date: 2008-03-28, release date: 2008-04-08, Last modification date: 2023-12-13)

• Primary citation: Cao, X.,Antonyuk, S.,Seetharaman, S.V.,Whitson, L.J.,Taylor, A.B.,Holloway, S.P.,Strange, R.W.,Doucette, P.A.,Tiwari, A.,Hayward, L.J.,Padua, S.,Cohlberg, J.A.,Selverstone Valentine, J.,Hasnain, S.S.,Hart, P.J.; Structures of the G85R Variant of Sod1 in Familial Amyotrophic Lateral Sclerosis.; J.Biol.Chem., 283:16169-, 2008; PubMed: 18378676; DOI: 10.1074/JBC.M801522200

Experimental method

X-RAY DIFFRACTION (1.36 Å)