4A1V

Co-Complex structure of NS3-4A protease with the optimized inhibitory peptide CP5-46A-4D5E

4A1V の概要

• エントリーDOI: 10.2210/pdb4a1v/pdb
• 関連するPDBエントリー: 1DXP 1DY8 1DY9 1W3C 4A1T 4A1X
• 分子名称: NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3, CP5-46A-4D5E, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: hydrolase-peptide complex, hydrolase/peptide
• 由来する生物種: HEPATITIS C VIRUS SUBTYPE 1B; 詳細
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26662
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 47323.07

構造登録者

Schmelz, S.,Kuegler, J.,Collins, J.,Heinz, D.W. (登録日: 2011-09-20, 公開日: 2012-09-19, 最終更新日: 2023-12-20)

• 主引用文献: Kugler, J.,Schmelz, S.,Gentzsch, J.,Haid, S.,Pollmann, E.,Van Den Heuvel, J.,Franke, R.,Pietschmann, T.,Heinz, D.W.,Collins, J.; High Affinity Peptide Inhibitors of the Hepatitis C Virus Ns3-4A Protease Refractory to Common Resistant Mutants.; J.Biol.Chem., 287:39224-, 2012; PubMed: 22965230; DOI: 10.1074/JBC.M112.393843

実験手法

X-RAY DIFFRACTION (2.2 Å)