1W3C

Crystal structure of the Hepatitis C Virus NS3 Protease in complex with a peptidomimetic inhibitor

Summary for 1W3C

Entry DOI	10.2210/pdb1w3c/pdb
Descriptor	PROTEASE/HELICASE NS3 (P70), NONSTRUCTURAL PROTEIN NS4A (P4), 3-({(2S)-2-[({(1R)-1-[({(1R)-1-[(R)-CARBOXY(HYDROXY)METHYL]-3,3-DIFLUOROPROPYL}AMINO)CARBONYL]-3-METHYLBUTYL}AMINO)CARB ONYL]-2,3-DIHYDRO-1H-INDOL-2-YL}METHYL)THIOPHENE-2-CARBOXYLIC ACID, ... (5 entities in total)
Functional Keywords	hydrolase, serine protease, hcv, indoline-based peptidomimetic inhibitor
Biological source	HEPATITIS C VIRUS (ISOLATE 1) More
Total number of polymer chains	4
Total formula weight	44006.50
Authors	Di Marco, S.,Volpari, C. (deposition date: 2004-07-14, release date: 2004-12-09, Last modification date: 2023-12-13)
Primary citation	Ontoria, J.M.,Di Marco, S.,Conte, I.,Di Francesco, M.E.,Gardelli, C.,Koch, U.,Matassa, V.G.,Poma, M.,Steinkuhler, C.,Volpari, C.,Harper, S. The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus Ns3 Protease J.Med.Chem., 47:6443-, 2004 Cited by PubMed: 15588076 DOI: 10.1021/JM049435D PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation