1DY9

Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (inhibitor I)

Summary for 1DY9

Entry DOI	10.2210/pdb1dy9/pdb
Related	1DXP 1DY8 1JXP
Related PRD ID	PRD_000426
Descriptor	PROTEASE/HELICASE NS3 (P70), NONSTRUCTURAL PROTEIN NS4A (P4), N-(tert-butoxycarbonyl)-L-alpha-glutamyl-N-[(1R)-1-(carboxycarbonyl)-3,3-difluoropropyl]-L-leucinamide, ... (5 entities in total)
Functional Keywords	serine protease, ns3, ns4a, hepatitis c virus, protease inhibition, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	HEPATITIS C VIRUS (ISOLATE TAIWAN) More
Total number of polymer chains	4
Total formula weight	43955.71
Authors	Di Marco, S.,Rizzi, M.,Volpari, C.,Walsh, M.,Narjes, F.,Colarusso, S.,De Francesco, R.,Matassa, V.G.,Sollazzo, M. (deposition date: 2000-01-31, release date: 2001-01-28, Last modification date: 2023-12-06)
Primary citation	Di Marco, S.,Rizzi, M.,Volpari, C.,Walsh, M.,Narjes, F.,Colarusso, S.,De Francesco, R.,Matassa, V.G.,Sollazzo, M. Inhibition of the Hepatitis C Virus Ns3/4A Protease the Crystal Structures of Two Protease-Inhibitor Complexes J.Biol.Chem., 275:7152-, 2000 Cited by PubMed: 10702283 DOI: 10.1074/JBC.275.10.7152 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation