4A1X
Co-Complex structure of NS3-4A protease with the inhibitory peptide CP5-46-A (Synchrotron data)
Summary for 4A1X
Entry DOI | 10.2210/pdb4a1x/pdb |
Related | 1DXP 1DY8 1DY9 1W3C 4A1T 4A1V |
Descriptor | NONSTRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3, CP5-46-A PEPTIDE, ZINC ION, ... (5 entities in total) |
Functional Keywords | hydrolase-peptide complex, unmodified inhibitory peptides, hydrolase/peptide |
Biological source | HEPATITIS C VIRUS SUBTYPE 1B More |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26662 |
Total number of polymer chains | 4 |
Total formula weight | 47971.71 |
Authors | Schmelz, S.,Kuegler, J.,Collins, J.,Heinz, D. (deposition date: 2011-09-20, release date: 2012-09-19, Last modification date: 2023-12-20) |
Primary citation | Kugler, J.,Schmelz, S.,Gentzsch, J.,Haid, S.,Pollmann, E.,Van Den Heuvel, J.,Franke, R.,Pietschmann, T.,Heinz, D.W.,Collins, J. High Affinity Peptide Inhibitors of the Hepatitis C Virus Ns3-4A Protease Refractory to Common Resistant Mutants. J.Biol.Chem., 287:39224-, 2012 Cited by PubMed: 22965230DOI: 10.1074/JBC.M112.393843 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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