4A1T
Co-Complex of the of NS3-4A protease with the inhibitory peptide CP5- 46-A (in-House data)
Summary for 4A1T
| Entry DOI | 10.2210/pdb4a1t/pdb |
| Related | 1DXP 1DY9 1W3C 4A1V 4A1X |
| Descriptor | NONSTRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3, CP5-46-A PEPTIDE, BICARBONATE ION, ... (9 entities in total) |
| Functional Keywords | hydrolase-peptide complex, unmodified inhibitory peptides, hydrolase/peptide |
| Biological source | HEPATITIS C VIRUS More |
| Total number of polymer chains | 4 |
| Total formula weight | 48477.84 |
| Authors | Schmelz, S.,Kuegler, J.,Collins, J.,Heinz, D.W. (deposition date: 2011-09-19, release date: 2012-09-19, Last modification date: 2023-12-20) |
| Primary citation | Kugler, J.,Schmelz, S.,Gentzsch, J.,Haid, S.,Pollmann, E.,Van Den Heuvel, J.,Franke, R.,Pietschmann, T.,Heinz, D.W.,Collins, J. High Affinity Peptide Inhibitors of the Hepatitis C Virus Ns3-4A Protease Refractory to Common Resistant Mutants. J.Biol.Chem., 287:39224-, 2012 Cited by PubMed: 22965230DOI: 10.1074/JBC.M112.393843 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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